Hodos NETWORKS & TRACTS

Lesson text is an educational draft awaiting anatomical review.

Regional anatomy · 7 relationships, about 16 minutes, for neurosurgical residents

Motor beyond M1: SMA, initiation and the CST body map

Relate medial frontal organisation to initiation, then audit what the available evidence can say about a CST body map at each named level.

Goals

Start this lesson in the atlas

Relationships

Relationship 1 of 7 · conceptual model

Orient the medial sequence without making a pipeline

Orient

Teaching sequences usually move from pre-SMA through SMA proper to M1 using 6ma, 6mp and area 4 as anterior-to-posterior references. Ruan’s cytoarchitectonic probability maps and the HCP parcel outlines are different reference systems. Functional reviews distinguish contributions across these regions without making each parcel an exclusive choose, start or execute stage.

Select each structure to light it on the atlas, then rotate until you can name what lies in front, behind and beneath it.

Targets

  • 6ma, anterior medial premotor
  • 6mp, posterior medial premotor
  • 4, primary motor reference

Compare

Select 6ma, 6mp and area 4 in turn on the medial surface, then state their anterior-to-posterior order before adding a functional description.

Read the neighbours

  • 6ma, 6mp and area 4 are distinct population parcel references.
  • Ruan describes cytoarchitectonic probability maps for pre-SMA and SMA.
  • Functional accounts distinguish medial motor contributions while allowing interaction.
  • A parcel outline does not locate an individual functional border.

Explain before revealing

Why is it incomplete to label 6ma, 6mp and area 4 as three exclusive action stages?

Explanation

The sequence provides spatial orientation, but the functional accounts describe interacting contributions rather than one fixed operation per parcel. The atlas shows population reference boundaries, not an individual functional transition.

In a surgical discussion

For resident teaching, name the reference territory and the action question separately. The displayed parcels are orientation aids, not individual functional or surgical boundaries.

Sources & anatomy notes

Evidence class: conceptual model

Medial motor sequence and function

6ma, 6mp and 4 are population parcel references used to orient pre-SMA, SMA proper and M1. Cytoarchitectonic probability maps and HCP parcel outlines are different reference systems; functional accounts distinguish contributions without making each parcel an exclusive action stage.

Evidence class: atlas · M1 · MB1 · MB3

Teaching notes

Ask the learner to answer before opening the explanation. Compare the answer with the named structures and the cited method. Teaching point: The sequence provides spatial orientation, but the functional accounts describe interacting contributions rather than one fixed operation per parcel. The atlas shows population reference boundaries, not an individual functional transition.

This relationship draws on 3 cited sources.

Relationship 2 of 7 · experimental anatomy

Separate FAT from the frontostriatal relationship

Orient

In a 19-patient awake glioma series, Kinoshita and colleagues associated resection close to the frontostriatal tract with transient movement-initiation disorders, whereas resection close to the left FAT was associated with transient speech-initiation disorders. These associations do not establish exclusive functions or predict individual outcomes. FAT is the selectable frontal association family here; a distinct frontostriatal bundle is not installed, and gross caudate and putamen meshes do not identify its endpoints.

Select each structure to light it on the atlas, then rotate until you can name what lies in front, behind and beneath it.

Targets

  • FAT, frontal aslant tract
  • CST, corticospinal tract
  • 6ma, anterior medial premotor
  • 6mp, posterior medial premotor
  • Caudate nucleus
  • Putamen

Compare

Keep CST dimmed. Compare the visible FAT bundle with the frontostriatal relationship described in the study, using the gross caudate and putamen meshes as orientation references.

Read the neighbours

  • Kinoshita’s awake glioma series included 19 patients.
  • Resection close to the frontostriatal tract was associated with transient movement-initiation disorders.
  • Resection close to the left FAT was associated with transient speech-initiation disorders.
  • These associations establish neither exclusive functions nor individual outcomes.

Explain before revealing

Which transient initiation disorder was associated with resection close to the frontostriatal tract, and which with resection close to the left FAT?

Explanation

The series associated frontostriatal proximity with transient movement-initiation disorders and left FAT proximity with transient speech-initiation disorders. These group associations do not establish exclusive functions or predict an individual outcome.

In a surgical discussion

Teach these findings as group associations, not exclusive tract functions or individual outcome predictions. The visible FAT bundle and gross striatal meshes do not establish a frontostriatal endpoint here.

Sources & anatomy notes

Evidence class: experimental anatomy

Candidate connections in an initiation account

FAT and frontostriatal pathways are distinct anatomical relationships discussed in axonal mapping. FAT is available as a population bundle here, while the frontostriatal route is not a separate selectable sample; gross caudate and putamen meshes do not identify its endpoints.

Evidence class: experimental anatomy · MB2 · R9 · D2 · D3

Teaching notes

Ask the learner to answer before opening the explanation. Compare the answer with the named structures and the cited method. Teaching point: The series associated frontostriatal proximity with transient movement-initiation disorders and left FAT proximity with transient speech-initiation disorders. These group associations do not establish exclusive functions or predict an individual outcome.

This relationship draws on 4 cited sources.

Relationship 3 of 7 · association

Keep connectional anatomy separate from recovery

Orient

Vergani and colleagues describe SMA white-matter connections, while a surgical series reports a group recovery pattern. The anatomical relationships shown here do not establish opposite-SMA recruitment as the cause of recovery or explain an individual course.

Select each structure to light it on the atlas, then rotate until you can name what lies in front, behind and beneath it.

Targets

  • CC, corpus callosum
  • FAT, frontal aslant tract
  • CST, corticospinal tract
  • 6ma, anterior medial premotor
  • 6mp, posterior medial premotor

Compare

Show CC and FAT with CST dimmed, then rotate to the medial view and compare both with 6ma and 6mp.

Read the neighbours

  • Vergani and colleagues describe SMA white-matter connections.
  • Krainik and colleagues report a group recovery pattern after SMA-region surgery.
  • The surgical series does not establish opposite-SMA recruitment as its cause.
  • The population bundle display does not measure recruitment or explain an individual recovery course.

Explain before revealing

Do the displayed callosal and frontal-aslant bundles establish that opposite-SMA recruitment caused recovery in the surgical series?

Explanation

No. The anatomy study describes SMA white-matter connections and the surgical series reports a group recovery pattern, but the display does not measure recruitment or show that the connections caused recovery.

In a surgical discussion

Separate anatomical context from a causal recovery account. Do not infer recruitment or an individual course from a population bundle display.

Sources & anatomy notes

Evidence class: association

Medial motor sequence and function

6ma, 6mp and 4 are population parcel references used to orient pre-SMA, SMA proper and M1. Cytoarchitectonic probability maps and HCP parcel outlines are different reference systems; functional accounts distinguish contributions without making each parcel an exclusive action stage.

Evidence class: atlas · M1 · MB1 · MB3

Candidate connections in an initiation account

FAT and frontostriatal pathways are distinct anatomical relationships discussed in axonal mapping. FAT is available as a population bundle here, while the frontostriatal route is not a separate selectable sample; gross caudate and putamen meshes do not identify its endpoints.

Evidence class: experimental anatomy · MB2 · R9 · D2 · D3

Teaching notes

Ask the learner to answer before opening the explanation. Compare the answer with the named structures and the cited method. Teaching point: No. The anatomy study describes SMA white-matter connections and the surgical series reports a group recovery pattern, but the display does not measure recruitment or show that the connections caused recovery.

This relationship draws on 9 cited sources.

Relationship 4 of 7 · conceptual model

Ask what SMA somatotopy adds to the parcel sequence

Orient

Reviews describe a rostral-to-caudal face, arm and leg sequence within SMA proper, mapped by stimulation and imaging studies. This is a study-level functional account, while the scene shows one 6mp parcel outline without that internal sequence or individual effector borders.

Select each structure to light it on the atlas, then rotate until you can name what lies in front, behind and beneath it.

Targets

  • 6mp, SMA territory reference
  • 4, primary motor reference

Compare

Compare the single 6mp outline with the reported rostral-to-caudal sequence. Identify the functional methods behind the sequence and what the scene leaves unshown.

Read the neighbours

  • Reviews describe a rostral-to-caudal face, arm and leg sequence within SMA proper.
  • Stimulation and imaging studies contribute to these functional maps.
  • A single 6mp parcel outline does not display the within-SMA sequence.
  • Population parcel boundaries do not provide individual effector borders.

Explain before revealing

What rostral-to-caudal face, arm and leg sequence is described within SMA proper, and what does the single 6mp outline leave unshown?

Explanation

Reviews describe a rostral-to-caudal face, arm and leg sequence within SMA proper, with functional evidence from stimulation and imaging studies. The displayed 6mp parcel is a single population outline and does not show those internal functional fields or an individual’s boundaries.

In a surgical discussion

Keep evidence about within-SMA functional organisation distinct from an individual parcel map. Do not convert a group sequence into an individual functional or surgical boundary.

Sources & anatomy notes

Evidence class: conceptual model

Medial motor sequence and function

6ma, 6mp and 4 are population parcel references used to orient pre-SMA, SMA proper and M1. Cytoarchitectonic probability maps and HCP parcel outlines are different reference systems; functional accounts distinguish contributions without making each parcel an exclusive action stage.

Evidence class: atlas · M1 · MB1 · MB3

Teaching notes

Ask the learner to answer before opening the explanation. Compare the answer with the named structures and the cited method. Teaching point: Reviews describe a rostral-to-caudal face, arm and leg sequence within SMA proper, with functional evidence from stimulation and imaging studies. The displayed 6mp parcel is a single population outline and does not show those internal functional fields or an individual’s boundaries.

This relationship draws on 4 cited sources.

Relationship 5 of 7 · reconstruction

At the corona radiata, audit the body-map evidence

Orient

The corona radiata is one named level in the body-map discussion. The displayed CST cannot identify upper- or lower-limb fibres. Facial motor pathways require a separate corticobulbar discussion. Cortical-origin comparisons do not assign these displayed lines to individual effectors.

Select each structure to light it on the atlas, then rotate until you can name what lies in front, behind and beneath it.

Targets

  • CST, corticospinal tract
  • 4, primary motor reference

Compare

Show the CST reference from a superior view. Ask whether the display identifies upper- or lower-limb fibres, and keep facial motor pathways as a separate corticobulbar discussion.

Read the neighbours

  • The displayed CST is a population-averaged reconstruction.
  • It cannot identify upper- or lower-limb fibres at the corona radiata.
  • Facial motor pathways require a separate corticobulbar discussion.
  • Cortical-origin comparisons do not assign these displayed lines to individual effectors.

Explain before revealing

Can cortical-origin comparisons of descending tracts identify upper- or lower-limb fibres in this corona-radiata CST?

Explanation

No. Usuda and colleagues compared descending contributions by cortical origin, but the displayed CST cannot identify upper- or lower-limb fibres. Facial motor pathways require a separate corticobulbar discussion.

In a surgical discussion

Name the displayed pathway and anatomical level, then make the separate evidence need explicit. Do not present a group bundle as an individual limb map.

Sources & anatomy notes

Evidence class: reconstruction

A body-map claim belongs to a level and method

The corona radiata, posterior limb and cerebral peduncle are separate levels in the body-map discussion. The sources cited here support population CST reconstructions and a method-specific capsular observation, but not a detailed corona-radiata or peduncular effector order.

Evidence class: reconstruction · D2 · M4 · M5 · R8 · D3

Teaching notes

Ask the learner to answer before opening the explanation. Compare the answer with the named structures and the cited method. Teaching point: No. Usuda and colleagues compared descending contributions by cortical origin, but the displayed CST cannot identify upper- or lower-limb fibres. Facial motor pathways require a separate corticobulbar discussion.

This relationship draws on 5 cited sources.

Relationship 6 of 7 · reconstruction

At the posterior limb, attach the map to its method

Orient

In a small DTI study of ten people (20 reconstructed CSTs), Holodny and colleagues found hand fibres anterolateral to foot fibres in 17 tracts; in the other three, hand and foot fibres were intermixed. These study-specific observations do not label the displayed population CST or establish an individual capsular map. The posterior limb itself is not separately segmented here.

Select each structure to light it on the atlas, then rotate until you can name what lies in front, behind and beneath it.

Targets

  • CST, corticospinal tract
  • Thalamus
  • Putamen
  • Globus pallidus
  • 4, primary motor reference

Compare

Show the population CST beside the gross thalamic and lentiform references. State the hand–foot relationship reported in the DTI study, then note that the displayed scene does not provide an individual capsular map.

Read the neighbours

  • Holodny and colleagues reconstructed 20 CSTs in a DTI study of ten people.
  • Hand fibres lay anterolateral to foot fibres in 17 tracts.
  • Hand and foot fibres were intermixed in the other three tracts.
  • The posterior limb is not separately segmented here; the population CST does not establish an individual capsular map.

Explain before revealing

What hand–foot relationship did this study report, and why is it not universal?

Explanation

The study reported hand fibres anterolateral to foot fibres in 17 of 20 tracts and an intermixed arrangement in the other three. This study-specific variation prevents treating that arrangement as universal, and it does not label the displayed population CST or map an individual capsule.

In a surgical discussion

Report the hand–foot pattern as a study-specific finding. It does not establish a universal order or map an individual capsule.

Sources & anatomy notes

Evidence class: reconstruction

A body-map claim belongs to a level and method

The corona radiata, posterior limb and cerebral peduncle are separate levels in the body-map discussion. The sources cited here support population CST reconstructions and a method-specific capsular observation, but not a detailed corona-radiata or peduncular effector order.

Evidence class: reconstruction · D2 · M4 · M5 · R8 · D3

Teaching notes

Ask the learner to answer before opening the explanation. Compare the answer with the named structures and the cited method. Teaching point: The study reported hand fibres anterolateral to foot fibres in 17 of 20 tracts and an intermixed arrangement in the other three. This study-specific variation prevents treating that arrangement as universal, and it does not label the displayed population CST or map an individual capsule.

This relationship draws on 5 cited sources.

Relationship 7 of 7 · reconstruction

At the peduncle, leave the body-part order unresolved

Orient

The cerebral peduncle is a separate level from the posterior limb and requires level-specific evidence. The sources cited here do not provide an effector-specific peduncular order. The Hodos scene has no brainstem or peduncular target, and its CST remains a population-average sample without body-part subdivisions. Do not extend a capsular account below its studied level.

Select each structure to light it on the atlas, then rotate until you can name what lies in front, behind and beneath it.

Targets

  • CST, corticospinal tract
  • Thalamus
  • Putamen
  • 4, primary motor reference
  • 6mp, posterior medial premotor

Compare

Keep the CST and gross subcortical meshes in an anterior view. Name the peduncle as a level that needs separate evidence and note that it is absent as a selectable structure in this scene.

Read the neighbours

  • The displayed bundles are population-averaged reconstructions.
  • The subcortical meshes are gross references without brainstem nuclei.
  • Cortical-origin comparisons of descending tracts do not supply a peduncular effector map.
  • A capsular somatotopy source cannot establish an ordering at another level.

Explain before revealing

Can the shape of this CST sample carry a capsular body map down to the cerebral peduncle?

Explanation

No. The scene has no peduncular structure or effector labels, and the cited capsular evidence is specific to its own level and method. A peduncular order remains a separate evidence question.

In a surgical discussion

A resident explanation should name the level and the evidence required to support a body-part claim. This display cannot provide an individual peduncular boundary or surgical margin.

Sources & anatomy notes

Evidence class: reconstruction

A body-map claim belongs to a level and method

The corona radiata, posterior limb and cerebral peduncle are separate levels in the body-map discussion. The sources cited here support population CST reconstructions and a method-specific capsular observation, but not a detailed corona-radiata or peduncular effector order.

Evidence class: reconstruction · D2 · M4 · M5 · R8 · D3

What is actually installed

A group-average cortical surface with a population parcellation, a population-averaged bundle atlas, and gross subcortical meshes. No patient image, no registration, no functional map, no brainstem or thalamic nuclei.

Evidence class: atlas · D1 · D2 · D3

Teaching notes

Ask the learner to answer before opening the explanation. Compare the answer with the named structures and the cited method. Teaching point: No. The scene has no peduncular structure or effector labels, and the cited capsular evidence is specific to its own level and method. A peduncular order remains a separate evidence question.

This relationship draws on 6 cited sources.

Recap

How would you connect medial frontal initiation with descending motor anatomy while keeping every body-map claim tied to its level and evidence?

  1. Orient 6ma, 6mp and area 4 without assigning one exclusive action stage to each parcel.
  2. Separate the visible FAT family from the frontostriatal relationship that is not rendered as its own bundle.
  3. Do not extend a capsular somatotopy claim to the peduncle or an individual CST sample.
Review the final explanation

No. The scene has no peduncular structure or effector labels, and the cited capsular evidence is specific to its own level and method. A peduncular order remains a separate evidence question.

Full source list

  1. M1 · Glasser et al., 2016, multi-modal parcellation of human cerebral cortex

    HCP population reference built from converging cortical features. A parcel boundary here is a group boundary; it does not locate one person’s functional border and it has not been registered to any individual in this viewer.

    Evidence class: atlas

  2. MB1 · Ruan et al., 2018, supplementary and pre-supplementary probability maps

    Human cytoarchitectonic and probability mapping distinguishes supplementary from pre-supplementary motor territories. Group maps do not establish an individual HCP parcel boundary.

    Evidence class: atlas

  3. MB3 · Nachev et al., 2008, supplementary and pre-supplementary motor function

    Review of functional contributions and interactions of SMA and pre-SMA in action control. It does not assign exclusive operations to atlas parcels or predict an individual outcome.

    Evidence class: conceptual model

  4. MB2 · Kinoshita et al., 2015, frontostriatal and frontal aslant pathways

    Axonal mapping examines frontostriatal and frontal aslant pathways in movement and speech. It supports distinguishing these relationships, not an exclusive initiation function or an installed individual circuit.

    Evidence class: experimental anatomy

  5. R9 · Catani et al., 2012, short frontal-lobe connections

    Tractography and post-mortem dissection describe FAT relationships with both SMA and pre-SMA. HCP 6mp and 6ma are orientation pointers here, not measured endpoints of this displayed sample.

    Evidence class: experimental anatomy

  6. D2 · Yeh, 2022, population-based tract-to-region connectome of the human brain

    Provenance for the HCP1065 population-averaged bundles rendered here. Every displayed line is an average-space reconstruction sampled for display; it is not a patient’s pathway and carries no direction of conduction.

    Evidence class: atlas

  7. D3 · Tian et al., 2020, topographic organization of the human subcortex

    Provenance for the Melbourne Subcortex Atlas scale-1 meshes rendered here. Scale 1 is the coarsest level: anterior and posterior thalamus are merged and no brainstem nucleus is included.

    Evidence class: atlas

  8. MB4 · Vergani et al., 2014, supplementary motor area white matter connections

    Human anatomical study of SMA white matter connections. It supports a broader connectional account, not endpoint proportions or a causal recovery mechanism.

    Evidence class: experimental anatomy

  9. M9 · Krainik et al., 2001, supplementary motor area and motor deficit after medial frontal surgery

    Surgical series correlating resection extent with postoperative deficit and recovery. The recovery pattern belongs to that series and its follow-up, not to any picture on this screen.

    Evidence class: association

  10. MB5 · Picard and Strick, 1996, medial-wall motor areas

    Review of medial-wall motor area locations and functional activation, including somatotopic organisation. It does not provide individual effector borders for the displayed parcels.

    Evidence class: conceptual model

  11. M4 · Usuda et al., 2022, corticospinal tracts arising from different cortical areas

    Healthy-volunteer tractography comparing descending contributions by cortical origin. Streamline distributions depend on acquisition, model and ROI recipe; they are not axon counts and they are not transferable to a patient.

    Evidence class: reconstruction

  12. M5 · Holodny et al., 2005, somatotopic organization of corticospinal tracts in the internal capsule

    Early DTI tractography of capsular organization, published explicitly against prior reports. A group ordering derived from one method is not a map you can transfer to an individual capsule.

    Evidence class: reconstruction

  13. R8 · Tredici et al., 1982, restricted capsular lesions and motor localization

    CT and clinical observations of restricted internal-capsular lesions support classical motor localization while allowing individual variation. A lesion-based inference is not a resolved fibre map in this atlas.

    Evidence class: association

  14. D1 · Van Essen et al., 2013, the WU-Minn Human Connectome Project overview

    Provenance for the S1200 group-average surface rendered here. A group-average midthickness surface is a population object; individual gyral and sulcal anatomy differs from it.

    Evidence class: atlas